主要业绩 | 一、 主要科研成果 先后承担完成国家十一五、十二五国家重大专项课题2项,主持国家自然科学基金课题5项,主持省自然科学基金重点项目等10项,主持新药临床药代动力学及生物等效性研究50余项,主持省级教改重点项目及教育部产学合作协同育人项目4项。在国内外权威刊物发表学术论文100余篇,其中SCI收录论文50余篇。主/参编书著3部、获国家科技进步二等奖1项(3/10)、江西省科技进步三等奖1项(2/6)、江西省教学成果奖二等奖1项(1/15)。 1、 主持科研课题 [1] 熊玉卿, 夏春华. 国际标准的创新药Ⅰ期临床试验和数据管理技术平台建设,国家“十二五”重大科技专项子课题, 682.60万元, 2011.1-2013.12, 2011ZX09302-007-03-2. [2] 熊玉卿, 夏春华. 构建I期临床试验研究和风险监测的信息化监管技术平台, 国家“十一五”重大科技专项子课题, 247.15万元, 2009.1-2010.12, 2009ZX09309-003-02. [3] 夏春华. 人参炔三醇基于PXR-CAR交互对话上调CYP3A4表达的机制研究, 国家自然科学基金, 34万元, 2022.1- 2025.12, 82160708. [4] 夏春华. 基于药效物质组及肝肾转运体排泄网络研究生脉方“君臣佐”配伍理论的药动学机制, 国家自然科学基金, 36万元, 2018.1- 2021.12, 81760672. [5] 夏春华. 人参炔三醇短时别构于CYP3A4酶结合位点、长时作用于核受体PXR/CAR调控通路的药物相互作用机制, 国家自然科学基金, 43(51.6)万元, 2016.1-2019.12, 81560606. [6] 夏春华. 基于OATPs/Oatps介导的麦冬皂苷D肝脏转运的分子学机制及其介导的参麦方复杂组分配伍机理研究, 国家自然科学基金, 55万元, 2012.1- 2015.12, 81160411. [7] 夏春华. 生脉方对CYP3A4酶不同结合位点的差异影响及其机理研究, 国家自然科学基金, 23万元, 2011.1-2013.12, 81060275. [8] 夏春华. 江西省双千计划-科技创新高端人才项目. 200万元, 2021.1-2023.12. [9] 夏春华. 人体生物等效性试验样本分析及临床设计国际标准体系的探索与建立,江西省重点研发计划,20万元,2021.1-2023.12, 20212BBG73035. [10] 夏春华. 基于PKC/NF-κB/PXR信号通路网络及交互对话研究熊果酸/齐墩果酸对UGT靶基因的多维调控机制, 江西省自然科学基金重点项目, 20万元, 2020.1-2022.12, 20202ACB206013. [11] 夏春华. 人参炔三醇对CYP3A4酶分子的短时別构、对PXR调控通路的长期干预机制研究, 江西省自然科学基金, 5万元, 2015.1-2017.12, 20151BAB205084. [12] 夏春华. 江西省青年科学家培养对象计划, 江西省科技厅人才计划, 8万元, 2013.6-2016.6, 20133BCB23006. [13] 夏春华. 基于“活性成分群”的生脉方临床整合药代动力学研究, 江西省自然科学基金, 2万元, 2010.1-2012.12, 2009GZY0141. [14] 夏春华. 基于药效物质组学的中药复方临床整合药代动力学研究, 江西省科技支撑计划, 2万元, 2010.1-2012.12, 2009BSB09600. 2、发表代表性论文 [1] Meng C, Zhong L, Lu T, Gu Q, Du X, Liu F, Xia C(*). Complex components of Shengmai formula interact with organic cation transporter 2 (OCT2) in MDCK cells. J Ethnopharmacol. 2023 May 23;308:116278. [2] Yan J, Gu Q, Meng C, Liu J, Liu F, Xia C(*). Panaxytriol upregulates CYP3A4 expression through the interaction between nuclear regulators and DNA response elements. J Ethnopharmacol. 2023 Mar 21;310:116398. [3] Liu J, Huang C, Liu J, Meng C, Gu Q, Du X, Yan M, Yu Y, Liu F, Xia C(*). Nrf2 and its dependent autophagy activation cooperatively counteract ferroptosis to alleviate acute liver injury. Pharmacol Res. 2023 Jan;187:106563. [4] Liu J, Liu J, Meng C, Gu Q, Huang C, Liu F, Xia C(*). NRF2 and FXR dual signaling pathways cooperatively regulate the effects of oleanolic acid on cholestatic liver injury. Phytomedicine. 2023 Jan;108:154529. [5] Liu J, Liu J, Meng C, Huang C, Liu F, Xia C(*). Oleanolic acid alleviates ANIT-induced cholestatic liver injury by activating Fxr and Nrf2 pathways to ameliorate disordered bile acids homeostasis. Phytomedicine. 2022 May 14;102:154173. [6] Hou J, Zhong L, Liu J, Liu F, Xia C(*). Interaction of the main active components in Shengmai formula mediated by organic anion transporter 1 (OAT1). J Ethnopharmacol. 2022 Jun 28;296:115515. [7] Zhang L, Yan J, Liu J, Meng C, Liu F, Xia C(*). Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90α, and RXRα. Phytomedicine. 2022 Apr 6;101:154097. [8] Yuan L, Zhang L, Yao N, Wu L, Liu J, Liu F, Zhang H, Hu X, Xiong Y, Xia C(*). Upregulation of UGT1A1 expression by ursolic acid and oleanolic acid via the inhibition of the PKC/NF-κB signaling pathway. Phytomedicine. 2021 Nov;92:153726. [9] Wu L, Liu J, Hou J, Zhan T, Yuan L, Liu F, Xiong Y, Hu J, Xia C(*). Interactions of the major effective components in Shengmai formula with breast cancer resistance protein at the cellular and vesicular levels. Biomed Pharmacother. 2021 Jan;133:110939. [10] Zhan T, Yao N, Wu L, Lu Y, Liu M, Liu F, Xiong Y, Xia C(*). The major effective components in Shengmai Formula interact with sodium taurocholate co-transporting polypeptide. Phytomedicine. 2019 Jun;59: 152916. [11] Yao N, Zeng C, Zhan T, He F, Liu M, Liu F, Zhang H, Xiong Y, Xia C(*). Oleanolic Acid and Ursolic Acid Induce UGT1A1 Expression in HepG2 Cells by Activating PXR Rather Than CAR. Front Pharmacol. 2019 Sep 27; 10:1111. [12] Wu J, Yao N, Hu Q, Liu M, Zhang H, Xiong Y, Hu J, Xia C(*). Effect of panaxytriol on cytochrome P450 3A4 via the pregnane X receptor regulatory pathway. Phytother Res. 2019 Apr;33(4):968-975. [13] Hu Q, Yao N, Wu J, Liu M, Liu F, Zhang H, Xiong Y, Xia C(*). Constitutive androstane receptor weakens the induction of panaxytriol on CYP3A4 by repressing the activation of pregnane X receptor. Biochem Pharmacol. 2019 Jan;159:32-39. [14] Shen Y, Yu Y, Lai W, Li S, Xu Z, Jin J, Yan X, Xing H, Chen X, Xiong A, Xia C(*), He J(*), Hong K. Evaluation of a Potential Clinical Significant Drug-Drug Interaction between Digoxin and Bupropion in Cynomolgus Monkeys. Pharm Res. 2019;36(1):1. [15] Chen L, Liu L, Chen Y, Liu M, Xiong Y, Zhang H, Huang S, Xia C(*). Modulation of transporter activity of OATP1B1 and OATP1B3 by the major active components of Radix Ophiopogonis. Xenobiotica. 2019 Oct;49(10):1221-1228. [16] Lu Y, Hu Q, Chen L, Zhang H, Huang S, Xiong Y, Xia C(*). Interaction of deoxyschizandrin and schizandrin B with liver uptake transporters OATP1B1 and OATP1B3. Xenobiotica. 2019 Feb;49(2):239-246. [17] Liu X, Chen L, Liu M, Zhang H, Huang S, Xiong Y, Xia C(*). Ginsenoside Rb1 and Rd Remarkably Inhibited the Hepatic Uptake of Ophiopogonin D in Shenmai Injection Mediated by OATPs/oatps. Front Pharmacol. 2018 Aug 22;9:957. [18] Yang F, Xiong X, Liu Y, Zhang H, Huang S, Xiong Y, Hu X, Xia C(*). CYP2C9 and OATP1B1 genetic polymorphisms affect the metabolism and transport of glimepiride and gliclazide. Sci Rep. 2018 Jul 20;8(1):10994. [19] Yang F, Liu L, Chen L, Liu M, Liu F, Xiong Y, Hu X, Xia C(*). OATP1B3 (699G>A) and CYP2C9*2, *3 significantly influenced the transport and metabolism of glibenclamide and glipizide. Sci Rep. 2018 Dec 24;8(1):18063. [20] Chen Y, Chen L, Zhang H, Huang S, Xiong Y, Xia C(*). Interaction of sulfonylureas with liver uptake transporters OATP1B1 and OATP1B3. Basic Clin Pharmacol Toxicol. 2018 Aug;123(2):147-154. 3、成果获奖: [1] 瑞舒伐他汀钙及制剂产业化新制备体系的构建与临床合理应用, 国家科技进步奖二等奖, 2016年12月, 夏春华(3/10) [2] 新他汀类药物调脂治疗的遗传多态性与临床合理应用, 江西省科技进步三等奖, 2014年6月, 夏春华(2/6) [3] OATP1B1遗传多态性对他汀类药物调脂效应影响的分子机制及临床合理应用, 江西省高校科技成果一等奖, 2013年9月, 夏春华(2/6) [4] 他汀类药物个体化用药差异及药物相互作用的机制研究, 江西医学科技奖, 2023年6月, 夏春华(2/5) [5] 全流程贯通、多学科交叉、产学研融合的药学创新性人才培养体系构建与实践, 江西省教学成果奖二等奖, 2023年12月, 夏春华(1/15) [6] Ⅰ期临床试验全流程管理信息化系统[AbsCTMSⅠ]V1.2, 国家计算机软件版权登记证书, 2014年2月, 夏春华(2/2) |